Neopterin and alpha-interferon in patients affected by Kaposi's sarcoma from Africa
Identifieur interne : 006629 ( Main/Exploration ); précédent : 006628; suivant : 006630Neopterin and alpha-interferon in patients affected by Kaposi's sarcoma from Africa
Auteurs : Antonio Marfella [Italie] ; Vincenzo Ruocco [Italie] ; Alba Capobianco [Italie] ; Mario Perna [Italie] ; Giovanni Santelli [Italie] ; Giovanni Frigione [Italie] ; Sebastian K. Kyalwazi [Ouganda] ; Roy D. Mugerwa [Ouganda] ; David Serwadda [Ouganda] ; Elke Beth-Giraldo [Italie] ; Gaetano Giraldo [Italie]Source :
- European Journal of Cancer and Clinical Oncology [ 0277-5379 ] ; 1989.
English descriptors
- Teeft :
- African kaposi, Correlation coefficient, Immunodeficiency, Immunodeficiency syndrome, Kaposi, Lancet, Macrophage, Neopterin, Neopterin levels, Opportunistic, Opportunistic infections, Progressive kaposi, Regressive, Regressive kaposi, Sarcoma, Sarcoma patients, Sarcoma sera, Sars coma, Tryptophan, Urinary neopterin, Virus replication.
Abstract
Abstract: The presence of circulating alpha-interferon and neopterin was investigated in sera of 47 patients affected by African Kaposi's sarcoma, both HIV-seropositive (13 patients) and HIV-seronegative (34 patients). For comparison, analyses were also performed in 20 HIV-seropositive symptomatic African subjects as well as in 20 African and 20 Italian healthy individuals.Alpha-interferon and neopterin levels appeared significantly higher in comparison with healthy control groups (P < 0.001) but not with HIV-seropositive African individuals without Kaposi's sarcoma. Moreover, alpha-interferon and neopterin levels were significantly higher in progressive Kaposi's sarcoma (27 patients) than in regressive Kaposi's sarcoma (20 patients) (P < 0.001). A significant correlation between alpha-interferon and neopterin was observed (r = 0.57; P < 0.01). Furthermore, alpha-interferon levels of HIV-seropositive Kaposi's sarcoma patients resulted significantly higher in comparison with the seronegative ones (P < 0.05).It is concluded that alpha-interferon and neopterin may be reliable prognostic markers in Kaposi's sarcoma patients.
Url:
DOI: 10.1016/0277-5379(89)90407-0
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000493
- to stream Istex, to step Curation: 000493
- to stream Istex, to step Checkpoint: 002461
- to stream Main, to step Merge: 006B47
- to stream Main, to step Curation: 006629
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Neopterin and alpha-interferon in patients affected by Kaposi's sarcoma from Africa</title><author><name sortKey="Marfella, Antonio" sort="Marfella, Antonio" uniqKey="Marfella A" first="Antonio" last="Marfella">Antonio Marfella</name></author><author><name sortKey="Ruocco, Vincenzo" sort="Ruocco, Vincenzo" uniqKey="Ruocco V" first="Vincenzo" last="Ruocco">Vincenzo Ruocco</name></author><author><name sortKey="Capobianco, Alba" sort="Capobianco, Alba" uniqKey="Capobianco A" first="Alba" last="Capobianco">Alba Capobianco</name></author><author><name sortKey="Perna, Mario" sort="Perna, Mario" uniqKey="Perna M" first="Mario" last="Perna">Mario Perna</name></author><author><name sortKey="Santelli, Giovanni" sort="Santelli, Giovanni" uniqKey="Santelli G" first="Giovanni" last="Santelli">Giovanni Santelli</name></author><author><name sortKey="Frigione, Giovanni" sort="Frigione, Giovanni" uniqKey="Frigione G" first="Giovanni" last="Frigione">Giovanni Frigione</name></author><author><name sortKey="Kyalwazi, Sebastian K" sort="Kyalwazi, Sebastian K" uniqKey="Kyalwazi S" first="Sebastian K." last="Kyalwazi">Sebastian K. Kyalwazi</name></author><author><name sortKey="Mugerwa, Roy D" sort="Mugerwa, Roy D" uniqKey="Mugerwa R" first="Roy D." last="Mugerwa">Roy D. Mugerwa</name></author><author><name sortKey="Serwadda, David" sort="Serwadda, David" uniqKey="Serwadda D" first="David" last="Serwadda">David Serwadda</name></author><author><name sortKey="Beth Giraldo, Elke" sort="Beth Giraldo, Elke" uniqKey="Beth Giraldo E" first="Elke" last="Beth-Giraldo">Elke Beth-Giraldo</name></author><author><name sortKey="Giraldo, Gaetano" sort="Giraldo, Gaetano" uniqKey="Giraldo G" first="Gaetano" last="Giraldo">Gaetano Giraldo</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:024C30C93791DAC932226532DF654E4B20756521</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1016/0277-5379(89)90407-0</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-0Q2QG76Z-P/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000493</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000493</idno><idno type="wicri:Area/Istex/Curation">000493</idno><idno type="wicri:Area/Istex/Checkpoint">002461</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002461</idno><idno type="wicri:doubleKey">0277-5379:1989:Marfella A:neopterin:and:alpha</idno><idno type="wicri:Area/Main/Merge">006B47</idno><idno type="wicri:Area/Main/Curation">006629</idno><idno type="wicri:Area/Main/Exploration">006629</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Neopterin and alpha-interferon in patients affected by Kaposi's sarcoma from Africa</title><author><name sortKey="Marfella, Antonio" sort="Marfella, Antonio" uniqKey="Marfella A" first="Antonio" last="Marfella">Antonio Marfella</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Clinical Pathology, National Cancer Institute ‘Fondaz. Sen. G. Pascale’, via M. Semmola, 80131, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Ruocco, Vincenzo" sort="Ruocco, Vincenzo" uniqKey="Ruocco V" first="Vincenzo" last="Ruocco">Vincenzo Ruocco</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dermatologic Clinic, I Faculty of Medicine, University of Naples</wicri:regionArea><wicri:noRegion>University of Naples</wicri:noRegion></affiliation></author><author><name sortKey="Capobianco, Alba" sort="Capobianco, Alba" uniqKey="Capobianco A" first="Alba" last="Capobianco">Alba Capobianco</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale S. Carlo, USL 2, Potenza</wicri:regionArea><wicri:noRegion>Potenza</wicri:noRegion></affiliation></author><author><name sortKey="Perna, Mario" sort="Perna, Mario" uniqKey="Perna M" first="Mario" last="Perna">Mario Perna</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Clinical Pathology, National Cancer Institute ‘Fondaz. Sen. G. Pascale’, via M. Semmola, 80131, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Santelli, Giovanni" sort="Santelli, Giovanni" uniqKey="Santelli G" first="Giovanni" last="Santelli">Giovanni Santelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Clinical Pathology, National Cancer Institute ‘Fondaz. Sen. G. Pascale’, via M. Semmola, 80131, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Frigione, Giovanni" sort="Frigione, Giovanni" uniqKey="Frigione G" first="Giovanni" last="Frigione">Giovanni Frigione</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Ospedale S. Carlo, USL 2, Potenza</wicri:regionArea><wicri:noRegion>Potenza</wicri:noRegion></affiliation></author><author><name sortKey="Kyalwazi, Sebastian K" sort="Kyalwazi, Sebastian K" uniqKey="Kyalwazi S" first="Sebastian K." last="Kyalwazi">Sebastian K. Kyalwazi</name><affiliation wicri:level="1"><country xml:lang="fr">Ouganda</country><wicri:regionArea>Mulago Hospital, Makerere University, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Mugerwa, Roy D" sort="Mugerwa, Roy D" uniqKey="Mugerwa R" first="Roy D." last="Mugerwa">Roy D. Mugerwa</name><affiliation wicri:level="1"><country xml:lang="fr">Ouganda</country><wicri:regionArea>Mulago Hospital, Makerere University, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Serwadda, David" sort="Serwadda, David" uniqKey="Serwadda D" first="David" last="Serwadda">David Serwadda</name><affiliation wicri:level="1"><country xml:lang="fr">Ouganda</country><wicri:regionArea>Mulago Hospital, Makerere University, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Beth Giraldo, Elke" sort="Beth Giraldo, Elke" uniqKey="Beth Giraldo E" first="Elke" last="Beth-Giraldo">Elke Beth-Giraldo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Viral Oncology, National Cancer Institute ‘Fondaz. Sen. G. Pascale’, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Giraldo, Gaetano" sort="Giraldo, Gaetano" uniqKey="Giraldo G" first="Gaetano" last="Giraldo">Gaetano Giraldo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific correspondence to: Prof. G. Giraldo, Division of Viral Oncology, Istituto per lo Studio e la Cura dei Tumori ‘Fondaz. Sen. G. Pascale’, Via M. Semmola, 80131, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Viral Oncology, National Cancer Institute ‘Fondaz. Sen. G. Pascale’, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Cancer and Clinical Oncology</title><title level="j" type="abbrev">EJCCO</title><idno type="ISSN">0277-5379</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1145">1145</biblScope><biblScope unit="page" to="1150">1150</biblScope></imprint><idno type="ISSN">0277-5379</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0277-5379</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>African kaposi</term><term>Correlation coefficient</term><term>Immunodeficiency</term><term>Immunodeficiency syndrome</term><term>Kaposi</term><term>Lancet</term><term>Macrophage</term><term>Neopterin</term><term>Neopterin levels</term><term>Opportunistic</term><term>Opportunistic infections</term><term>Progressive kaposi</term><term>Regressive</term><term>Regressive kaposi</term><term>Sarcoma</term><term>Sarcoma patients</term><term>Sarcoma sera</term><term>Sars coma</term><term>Tryptophan</term><term>Urinary neopterin</term><term>Virus replication</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The presence of circulating alpha-interferon and neopterin was investigated in sera of 47 patients affected by African Kaposi's sarcoma, both HIV-seropositive (13 patients) and HIV-seronegative (34 patients). For comparison, analyses were also performed in 20 HIV-seropositive symptomatic African subjects as well as in 20 African and 20 Italian healthy individuals.Alpha-interferon and neopterin levels appeared significantly higher in comparison with healthy control groups (P < 0.001) but not with HIV-seropositive African individuals without Kaposi's sarcoma. Moreover, alpha-interferon and neopterin levels were significantly higher in progressive Kaposi's sarcoma (27 patients) than in regressive Kaposi's sarcoma (20 patients) (P < 0.001). A significant correlation between alpha-interferon and neopterin was observed (r = 0.57; P < 0.01). Furthermore, alpha-interferon levels of HIV-seropositive Kaposi's sarcoma patients resulted significantly higher in comparison with the seronegative ones (P < 0.05).It is concluded that alpha-interferon and neopterin may be reliable prognostic markers in Kaposi's sarcoma patients.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Ouganda</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Marfella, Antonio" sort="Marfella, Antonio" uniqKey="Marfella A" first="Antonio" last="Marfella">Antonio Marfella</name></noRegion><name sortKey="Beth Giraldo, Elke" sort="Beth Giraldo, Elke" uniqKey="Beth Giraldo E" first="Elke" last="Beth-Giraldo">Elke Beth-Giraldo</name><name sortKey="Capobianco, Alba" sort="Capobianco, Alba" uniqKey="Capobianco A" first="Alba" last="Capobianco">Alba Capobianco</name><name sortKey="Frigione, Giovanni" sort="Frigione, Giovanni" uniqKey="Frigione G" first="Giovanni" last="Frigione">Giovanni Frigione</name><name sortKey="Giraldo, Gaetano" sort="Giraldo, Gaetano" uniqKey="Giraldo G" first="Gaetano" last="Giraldo">Gaetano Giraldo</name><name sortKey="Giraldo, Gaetano" sort="Giraldo, Gaetano" uniqKey="Giraldo G" first="Gaetano" last="Giraldo">Gaetano Giraldo</name><name sortKey="Perna, Mario" sort="Perna, Mario" uniqKey="Perna M" first="Mario" last="Perna">Mario Perna</name><name sortKey="Ruocco, Vincenzo" sort="Ruocco, Vincenzo" uniqKey="Ruocco V" first="Vincenzo" last="Ruocco">Vincenzo Ruocco</name><name sortKey="Santelli, Giovanni" sort="Santelli, Giovanni" uniqKey="Santelli G" first="Giovanni" last="Santelli">Giovanni Santelli</name></country><country name="Ouganda"><noRegion><name sortKey="Kyalwazi, Sebastian K" sort="Kyalwazi, Sebastian K" uniqKey="Kyalwazi S" first="Sebastian K." last="Kyalwazi">Sebastian K. Kyalwazi</name></noRegion><name sortKey="Mugerwa, Roy D" sort="Mugerwa, Roy D" uniqKey="Mugerwa R" first="Roy D." last="Mugerwa">Roy D. Mugerwa</name><name sortKey="Serwadda, David" sort="Serwadda, David" uniqKey="Serwadda D" first="David" last="Serwadda">David Serwadda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006629 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006629 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:024C30C93791DAC932226532DF654E4B20756521
|texte= Neopterin and alpha-interferon in patients affected by Kaposi's sarcoma from Africa
}}
| This area was generated with Dilib version V0.6.33. |  |